Parkinson disease affects which neurotransmitter
Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD. Neurology 80 , — Lobb, C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. Long, J. The metabolic serine hydrolases and their functions in mammalian physiology and disease. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Lourenco, J.
Lovatt, D. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Luo, C. Mackie, K. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.
Maclaren, D. Deficits in motor performance after pedunculopontine lesions in rats — impairment depends on demands of task. Maeda, T. Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA. Mahul-Mellier, A. Mailleux, P. Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry.
Neuroscience 48 , — Mallet, N. Feedforward inhibition of projection neurons by fast-spiking GABA interneurons in the rat striatum in vivo. Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. Marcellino, D. Maresz, K. Marinelli, M.
Heterogeneity of dopamine neuron activity across traits and states. Marsden, C. Lancet , — Martin, A. Expression and function of CB1 receptor in the rat striatum: localization and effects on D 1 and D 2 dopamine receptor-mediated motor behaviors.
Neuropsychopharmacology 33 , — Mathur, B. Endocannabinoid-dopamine interactions in striatal synaptic plasticity. Matsuda, L. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Mcgeer, P. Neurology 38 , — Mechoulam, R. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Mena-Segovia, J. Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?
Meschler, J. Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methylphenyl-1,2,5,6-tetrahydropyridine MPTP -treated non-human primates.
Psychopharmacology , 79— Minger, S. Cholinergic deficits contribute to behavioral disturbance in patients with dementia. Neurology 55 , — Mizoguchi, K. Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. Moehle, M. Neuroscience , 59— LRRK2 inhibition attenuates microglial inflammatory responses. Moore, R. Central catecholamine neuron systems: anatomy and physiology of the dopamine systems.
Moore, D. More, S. Mediators Inflamm. Morikawa, H. Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience , 95— Mosharov, E. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron 62 , — Mount, M. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. Munhoz, R. Munoz-Arenas, G. Cannabinoid CB1 receptors activation and coactivation with D 2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetry.
Synapse 69 , — Munro, S. Molecular characterization of a peripheral receptor for cannabinoids. Nature , 61— Nambu, A. A new dynamic model of the cortico-basal ganglia loop. Narendra, D. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Navarro, G. Relevance for treatment. Neuropharmacology , — Newman, E. Glial cell inhibition of neurons by release of ATP. Ng, K. Drug-induced release of 3H-norepinephrine and 3H-serotonin from brain slices. Nicholson, S. Nobili, F. Nomura, D. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Nys, M. Structural insights into Cys-loop receptor function and ligand recognition.
Immunity 36 , — Obeso, J. Basal ganglia pathophysiology. A critical review. Ready for prime time? Olanow, C. Olney, J. Excitotoxicity: an overview. Ossowska, K. Blockade of the metabotropic glutamate receptor subtype 5 mGluR5 produces antiparkinsonian-like effects in rats.
Neuropharmacology 41 , — Pahapill, P. Paille, V. Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.
Paisan-Ruiz, C. Neuron 44 , — Paladini, C. Generating bursts and pauses in the dopamine midbrain neurons. Palazuelos, J. The CB 2 cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. Palma, E. Novel approaches to study the involvement of alpha7-nAChR in human diseases. Drug Targets 13 , — Pappas, B. Aging 21 , 11— Parent, A.
The heterogeneity of the mesostriatal dopaminergic system as revealed in normal and parkinsonian monkeys. Park, J. Pascual, O. Astrocytic purinergic signaling coordinates synaptic networks. Pasupathy, A. Different time courses of learning-related activity in the prefrontal cortex and striatum.
Patel, K. Cannabinoid CB 2 receptors in health and disease. Pavese, N. Clinical correlates of levodopa-induced dopamine release in Parkinson disease: a PET study. Neurology 67 , — Pellicano, C.
Peng, L. Nucleoside transporter expression and function in cultured mouse astrocytes. Glia 52 , 25— Perez-Lloret, S. Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease. Petroff, O. GABA and glutamate in the human brain. Neuroscientist 8 , — Picciotto, M. Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76 , — Picconi, B.
Pignatelli, M. Role of dopamine neurons in reward and aversion: a synaptic plasticity perspective. Neuron 86 , — Pinal, C. Uniqueness and redundancy in GABA production. Pinna, A. Baqi, Y. Politis, M. Polymeropoulos, M. Potenza, M. The neurobiology of pathological gambling and drug addiction: an overview and new findings.
Prescott, W. Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by delta 9-THC in the rat. Psychopharmacology , — Price, D.
Qin, H. Ramirez-Zamora, A. Expert Rev. Rasheed, N. Differential response of central dopaminergic system in acute and chronic unpredictable stress models in rats.
Rashid, A. Richerson, G. Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. Rodriguez, M. Roeper, J. Dissecting the diversity of midbrain dopamine neurons. Romero, J. The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons.
The endogenous cannabinoid system and the basal ganglia. Pharmacol Ther. Ron, D. Signal integration in the endoplasmic reticulum unfolded protein response.
Sagredo, O. Cannabinoids and neuroprotection in basal ganglia disorders. Salamone, J. The mysterious motivational functions of mesolimbic dopamine.
Samara, C. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Diff. Sanchez-Pernaute, R. Neuroinflammation 1 , 6. Sanchez-Gonzalez, M. The primate thalamus is a key target for brain dopamine. Sanchez-Guajardo, V. Neuroscience , 47— Sato, A. Cell Physiol. Schiemann, J. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.
Schlatterer, S. Schlosburg, J. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Schultz, W. A neural substrate of prediction and reward. There are also foods to avoid. What is the connection between dopamine and Parkinson's disease?
Medically reviewed by Seunggu Han, M. Role of dopamine in the disease. Risk factors. Latest news Scientists identify new cause of vascular injury in type 2 diabetes. Adolescent depression: Could school screening help? Related Coverage. Parkinson's disease early signs and causes. Parkinson's disease complications. Medically reviewed by Nancy Hammond, M. What is early onset Parkinson's disease? Medically reviewed by Nancy Hammond, MD.
Parkinson's diet: What to know. The neuropathology of PD has shown that complex, interconnected neuronal systems, regulated by a number of different neurotransmitters in addition to dopamine, are involved in the aetiology of motor and non-motor symptoms.
This review focuses on the non-dopaminergic neurotransmission systems associated with PD with particular reference to the effect that their modulation and interaction with dopamine has on the non-motor symptoms of the disease. Health Conditions Discover Plan Connect. What is dopamine? What happens when dopamine levels drop?
How dopamine travels. Diagnosis with dopamine transporter scan DaTscan. Dopamine in treatments. Ways to boost dopamine. The bottom line. Read this next. Medically reviewed by Graham Rogers, M.
How Does Dopamine Affect the Body? Medically reviewed by Timothy J. Legg, Ph. Medically reviewed by Nancy Hammond, M.
0コメント